I have a 1" leveling kit on my Outer Banks, with 305/65/R18 Nitto Ridge Grapplers on factory wheels. No issues whatsoever. I would imagine a huge 4" lift like you are doing would be fine as well if you remove the crash bars for that extra inch of tire height.
I opted to keep the factory wheels on my OB, and just put bigger tires on. The factory tires are 255/70/R18 and the one I put on are 305/65/R18: Before & after
Reservation Date: 7/14/2020
Order Date: 1/27/2021
Build Date #1: August 9, 2021
Build Date #2: August 16, 2021
Build Date #3: August 30, 2021
Build Date #4: September 13, 2021
Current Build Date: October 25, 2021